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KMID : 1137820210420030094
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의공학회지
2021 Volume.42 No. 3 p.94 ~ p.99
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Evaluation of Anti-Inflammatory Effect of Pulsed Electromagnetic Field on DNCB-Induced Atopic Dermatitis Using Principal Component Analysis
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Lee Ji-Young
Kim Jun-Yong
Lee Ye-Rin
Kim Ko-Eun
Lee Yong-Heum
Yang Se-Jung
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Abstract
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Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by itchy and age-dependent lesions. Previous studies have shown that pulsed electromagnetic field (PEMF) significantly improved chronic ulcers and ununited fractures, providing an evidence for the application of PEMF in resolving inflammation caused by AD. This study investigated the anti-inflammatory effect of PEMF on DNCB-induced AD in animal models. Five male hairless mice (6 weeks old) per group were assigned to a normal group, a sham group, and two PEMF groups (15Hz, 75Hz). Mice were treated with 2,4-Dinitrochlorobenzene (DNCB) to induce uniform AD among all groups excluding a normal group. To examine the inflammatory progress and the improvement of AD after the PEMF stimulation, images are taken with various cameras for non-invasive evaluation and the results are expressed using principal com?ponent analysis (PCA) for visualization. The results of this study demonstrated that PEMF effectively improved skin lesions without the use of drugs.
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KEYWORD
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Pulsed electromagnetic field, DNCB, Atopic dermatitis, Principal component analysis
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